HybridDesign: Hybrid Design for Phase I Dose-Finding Studies

The Hybrid design is a combination of model-assisted design (e.g., the modified Toxicity Probability Interval design) with dose-toxicity model-based design for phase I dose-finding studies. The hybrid design controls the overdosing toxicity well and leads to a recommended dose closer to the true maximum tolerated dose (MTD) due to its ability to calibrate for an intermediate dose. More details can be found in Liao et al. 2022 <doi:10.1002/ijc.34203>.

Version:	1.0
Depends:	R (≥ 3.6)
Imports:	testit, ResourceSelection
Published:	2022-12-15
DOI:	10.32614/CRAN.package.HybridDesign
Author:	Heng Zhou [aut, cre], Feng Zhou [aut], Jason Liao [aut]
Maintainer:	Heng Zhou <heng.zhou at merck.com>
License:	GPL-3
NeedsCompilation:	no
CRAN checks:	HybridDesign results

Documentation:

Reference manual:

HybridDesign.pdf

Downloads:

Package source:	HybridDesign_1.0.tar.gz
Windows binaries:	r-devel: HybridDesign_1.0.zip, r-release: HybridDesign_1.0.zip, r-oldrel: HybridDesign_1.0.zip
macOS binaries:	r-release (arm64): HybridDesign_1.0.tgz, r-oldrel (arm64): HybridDesign_1.0.tgz, r-release (x86_64): HybridDesign_1.0.tgz, r-oldrel (x86_64): HybridDesign_1.0.tgz

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